Antigen Record Ag000001

AgACCAg000001
Date11-02-2007
Last updated14-12-2016
Antigen NameERBB2
Common NameHER2
Full NameReceptor tyrosine-protein kinase erbB-2
SynonymCD340 antigen; MLN 19; NEU proto-oncogene; Tyrosine kinase-type cell surface receptor HER2; c-erb B2; c-erbB2/neu protein; neuroblastoma/glioblastoma derived oncogene homolog; tyrosine kinase-type cell surface receptor; v-erb-b2 avian erythroblastic leukemia viral oncogene homolog; neuro/glioblastoma derived oncogene homolog; v-erb-b2 erythroblastic leukemia viral oncogene homolog; neuo/glioblastoma derived oncogene homolog (avain); c-erbB-2; EC 2.7.10.1; HER-2; HER-2/neu; HER2; NEU; NGL; TKR1; erb-2; herstatin; p185erbB2

another display format
  • CD340 antigen
  • MLN 19
  • NEU proto-oncogene
  • Tyrosine kinase-type cell surface receptor HER2
  • c-erb B2
  • c-erbB2/neu protein
  • neuroblastoma/glioblastoma derived oncogene homolog
  • tyrosine kinase-type cell surface receptor
  • v-erb-b2 avian erythroblastic leukemia viral oncogene homolog
  • neuro/glioblastoma derived oncogene homolog
  • v-erb-b2 erythroblastic leukemia viral oncogene homolog
  • neuo/glioblastoma derived oncogene homolog (avain)
  • c-erbB-2
  • EC 2.7.10.1
  • HER-2
  • HER-2/neu
  • HER2
  • NEU
  • NGL
  • TKR1
  • erb-2
  • herstatin
  • p185erbB2
UniProt IDP04626
NCBI Gene ID2064
GeneCard IDGC17P039687
AnnotationThis is a full length sequence.
IsoformsAg001732

Alignment of all Isoforms
Mutation entriesAg001291,  Ag001292,  Ag001293,  Ag001294,  Ag001295,  Ag001296,  Ag001297,  Ag001298,  Ag001299,  Ag001300,  Ag001301,  Ag001302,  Ag001303,  Ag001304,  Ag001305,  Ag001306,  Ag001307,  Ag001308,  Ag001309,  Ag001310,  Ag001311,  Ag001312,  Ag001313,  Ag001314,  Ag002176,  Ag002177,  Ag002178,  Ag002179,  Ag002180,  Ag002181,  Ag004463

View mutation map
RNA/protein expression profileRNA and protein Expression profile
T cell epitopeEpitope sequencePositionHLA alleleReference
ALCRWGLLL5-13 A*0201  9544234
ALIHHNTHL466-474 A*0201  12023395
CLTSTVQLV789-797 A*0201  8988046 11441084
CLTSTVQLV789-797 A*0202  11441084
CLTSTVQLV789-797 A*0203  11441084
CLTSTVQLV789-797 A*0206  11441084
ELVSEFSRM971-979 A*0201  7539040
GSPYVSRLLGICL778-790 DRB1*0405  11720440
GSPYVSRLLGICL778-790 DRB1*0701  11720440
GSPYVSRLLGICL778-790 DRB5*0101  11720440
GSPYVSRLLGICL778-790 DR11  11092612
HLYQGCQVV48-56 A*0201  12023395 11441084
HLYQGCQVV48-56 A*0202  11441084
HLYQGCQVV48-56 A*0203  11441084
IISAVVGIL654-662 A*0201  9485028
ILHNGAYSL435-443 A*0201  9544234 11441084
ILHNGAYSL435-443 A*0202  11441084
ILHNGAYSL435-443 A*0203  11441084
ILLVVVLGV661-669 A*0201  11093159
KIFGSLAFL369-377 A*0201  11441084
KIFGSLAFL369-377 A*0202  11441084
KIFGSLAFL369-377 A*0203  11441084
KIFGSLAFL369-377 A*0206  11441084
KIFGSLAFLPESFDGDPA369-386 DRB1*0401  9419209
KVPIKWMALESILRRRF883-899 DR1  11016652
KVPIKWMALESILRRRF883-899 DR4  11016652
KVPIKWMALESILRRRF883-899 DR52  11016652
KVPIKWMALESILRRRF883-899 DR53  11016652
LIAHNQVRQV85-94 A*0201  18566379
PLQPEQLQV391-399 A*0201  12023395
PLTSIISAV650-658 A*0201  12023395
QLMPYGCLL799-807 A*0201  17638916
RLLQETELV689-697 A*0201  10395702
RWGLLLALL8-16 A24  11139320
TLEEITGYL402-410 A*0201  17638916
TLEEITGYLY402-411 A*0201  12023395
TYLPTNASL63-71 A*2402  11093150
VLRENTSPK754-762 A*0301  9927058
VLVKSPNHV851-859 A*0201  7539040
VMAGVGSPYV773-782 A*0201  11441084
VMAGVGSPYV773-782 A*0202  11441084
VMAGVGSPYV773-782 A*0203  11441084
VPIKWMALESILRRRF884-899 DR11  11092612
VVLGVVFGI665-673 A*0201  10395702
YLVPQQGFFC1023-1032 A*0201  11745343
YMIMVKCWMI952-961 A*0201  11441084
YMIMVKCWMI952-961 A*0202  11441084
YMIMVKCWMI952-961 A*0203  11441084
YMIMVKCWMI952-961 A*0206  11441084
YMIMVKCWMI952-961 A*6802  11441084
HLA ligandLigand SequencePositionHLA alleleReference
ILIKRRQQK673-681 A*0301  9927058
ILWKDIFHK167-175 A*0301  9927058
KIRKYTMRR681-689 A*0301  9927058
KVLRENTSPK753-762 A*0301  9927058
LVKSPNHVK852-860 A*0301  9927058
QLRSLTEILK141-150 A*0301  9927058
SIISAVVGI653-661 A*0201  11441084
SIISAVVGI653-661 A*0203  11441084
SIISAVVGI653-661 A*0206  11441084
SIISAVVGI653-661 A*6802  11441084
VLRENTSPK754-762 A*1101  9927058
VLRENTSPK754-762 A*3101  9927058
VLRENTSPK754-762 A*3301  9927058
Predicted HLA binders
Allele:  predictions
Peptide length:   
Antigen sequenceMELAALCRWGLLLALLPPGAASTQVCTGTDMKLRLPASPETHLDMLRHLYQGCQVVQGNLELTYLPTNAS
LSFLQDIQEVQGYVLIAHNQVRQVPLQRLRIVRGTQLFEDNYALAVLDNGDPLNNTTPVTGASPGGLREL
QLRSLTEILKGGVLIQRNPQLCYQDTILWKDIFHKNNQLALTLIDTNRSRACHPCSPMCKGSRCWGESSE
DCQSLTRTVCAGGCARCKGPLPTDCCHEQCAAGCTGPKHSDCLACLHFNHSGICELHCPALVTYNTDTFE
SMPNPEGRYTFGASCVTACPYNYLSTDVGSCTLVCPLHNQEVTAEDGTQRCEKCSKPCARVCYGLGMEHL
REVRAVTSANIQEFAGCKKIFGSLAFLPESFDGDPASNTAPLQPEQLQVFETLEEITGYLYISAWPDSLP
DLSVFQNLQVIRGRILHNGAYSLTLQGLGISWLGLRSLRELGSGLALIHHNTHLCFVHTVPWDQLFRNPH
QALLHTANRPEDECVGEGLACHQLCARGHCWGPGPTQCVNCSQFLRGQECVEECRVLQGLPREYVNARHC
LPCHPECQPQNGSVTCFGPEADQCVACAHYKDPPFCVARCPSGVKPDLSYMPIWKFPDEEGACQPCPINC
THSCVDLDDKGCPAEQRASPLTSIISAVVGILLVVVLGVVFGILIKRRQQKIRKYTMRRLLQETELVEPL
TPSGAMPNQAQMRILKETELRKVKVLGSGAFGTVYKGIWIPDGENVKIPVAIKVLRENTSPKANKEILDE
AYVMAGVGSPYVSRLLGICLTSTVQLVTQLMPYGCLLDHVRENRGRLGSQDLLNWCMQIAKGMSYLEDVR
LVHRDLAARNVLVKSPNHVKITDFGLARLLDIDETEYHADGGKVPIKWMALESILRRRFTHQSDVWSYGV
TVWELMTFGAKPYDGIPAREIPDLLEKGERLPQPPICTIDVYMIMVKCWMIDSECRPRFRELVSEFSRMA
RDPQRFVVIQNEDLGPASPLDSTFYRSLLEDDDMGDLVDAEEYLVPQQGFFCPDPAPGAGGMVHHRHRSS
STRSGGGDLTLGLEPSEEEAPRSPLAPSEGAGSDVFDGDLGMGAAKGLQSLPTHDPSPLQRYSEDPTVPL
PSETDGYVAPLTCSPQPEYVNQPDVRPQPPSPREGPLPAARPAGATLERPKTLSPGKNGVVKDVFAFGGA
VENPEYLTPQGGAAPQPHPPPAFSPAFDNLYYWDQDPPERGAPPSTFKGTPTAENPEYLGLDVPV